Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.56 |
| ▸ | USP2 | O75604 | 3/20 | 0.56 |
| ▸ | GPR39 | O43194 | 3/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | FABP1 | P07148 | 1/20 | 0.47 |
| ▸ | FABP6 | P51161 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3664081 | 0.85 | GPR39 (0.49) | CYP3A4CYP1A2CYP2D6CLK4ALDH1A1 | |
| SCHEMBL3664054 | 0.84 | GPR39 (0.46) | CYP3A4CYP1A2CYP2D6CLK4ALDH1A1 | |
| SCHEMBL2239929 | 0.83 | CYP3A4 (0.65) | CYP3A4CYP1A2CYP2D6CLK4ALDH1A1 | |
| SCHEMBL3665841 | 0.81 | CLK4 (0.55) | CYP3A4CYP1A2CYP2D6CLK4ALDH1A1 | |
| SCHEMBL3669694 | 0.81 | CYP2A6 (0.54) | CYP3A4CYP1A2ALDH1A1CYP2A6CYP19A1 | |
| SCHEMBL3664008 | 0.80 | PTGDR (0.47) | CLK4ALDH1A1HIF1ACYP2A6MAPK1 | |
| SCHEMBL4775842 | 0.79 | CYP3A4 (0.60) | CYP3A4CYP1A2CYP2D6CLK4ALDH1A1 | |
| SCHEMBL3721234 | 0.78 | CYP3A4 (0.41) | CYP3A4CYP1A2CYP2D6CLK4ALDH1A1 | |
| SCHEMBL3664970 | 0.78 | HDAC1 (0.43) | CYP3A4CYP1A2CYP2D6CLK4ALDH1A1 | |
| SCHEMBL4775067 | 0.78 | CYP3A4 (0.57) | CYP3A4CYP1A2CYP2D6CLK4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242742-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2015-12-02 | — | — | EP | disclosed |
| US-8343966-B2 | Organic compounds | NOVARTIS AG (CH) | 2013-01-01 | — | — | US | disclosed |
| EP-2242742-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2010-10-27 | — | — | EP | disclosed |
| US-20090215776-A1 | Organic compounds | ADCOCK CLAIRE | 2009-08-27 | — | — | US | disclosed |
| WO-2009087212-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2009-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215776-A1 | Organic compounds | REN, RXFP1, MYLK | CYP3A4 1053/4885CYP1A2 616/4885CYP2D6 1318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.