Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19392346 | 0.86 | KMT2A (0.76) | L3MBTL1KMT2AMEN1POLBPKM | |
| SCHEMBL12310087 | 0.86 | KDM4E (0.67) | THRBALDH1A1KDM4ESTAT3PKM | |
| SCHEMBL3974104 | 0.83 | L3MBTL1 (0.75) | L3MBTL1KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL13729458 | 0.80 | MEN1 (0.51) | KMT2AMEN1THRB | |
| SCHEMBL16733908 | 0.80 | ALDH1A1 (0.61) | L3MBTL1KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL23646022 | 0.80 | L3MBTL1 (0.71) | L3MBTL1KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL10900411 | 0.80 | CYP2C9 (0.69) | KMT2AMEN1ALDH1A1POLBHTT | |
| SCHEMBL7026165 | 0.79 | KCNH2 (0.69) | L3MBTL1KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL14924489 | 0.79 | HRH3 (0.62) | L3MBTL1KMT2AMEN1ALDH1A1 | |
| SCHEMBL12169349 | 0.79 | L3MBTL1 (0.69) | L3MBTL1KMT2AMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2235010-A1 | BICYCLIC DERIVATIVES FOR USE IN THE TREATMENT OF ANDROGEN RECEPTOR ASSOCIATED CONDITIONS | AstraZeneca AB (SE) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009081197-A1 | BICYCLIC DERIVATIVES FOR USE IN THE TREATMENT OF ANDROGEN RECEPTOR ASSOCIATED CONDITIONS | ASTRAZENECA AB (SE) | 2009-07-02 | — | — | WO | disclosed |