Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27565870 | 0.84 | KMT2A (0.61) | MEN1KMT2AKCNH2SIGMAR1 | |
| SCHEMBL2730391 | 0.83 | SIGMAR1 (0.57) | KCNJ1KCNH2SIGMAR1THRBADRA1D | |
| SCHEMBL10898269 | 0.81 | DHCR7 (0.53) | MEN1KMT2AKCNJ1KCNH2SIGMAR1 | |
| SCHEMBL3662852 | 0.80 | L3MBTL1 (0.59) | MEN1KMT2ATHRB | |
| SCHEMBL1239240 | 0.80 | SIGMAR1 (0.57) | KCNJ1KCNH2SIGMAR1THRBADRA1D | |
| SCHEMBL1241103 | 0.76 | HRH3 (0.68) | SIGMAR1HRH3 | |
| SCHEMBL4960414 | 0.76 | HRH3 (0.62) | SIGMAR1HRH3 | |
| SCHEMBL10902150 | 0.76 | KCNJ1 (0.65) | KCNJ1KCNH2 | |
| SCHEMBL28327802 | 0.75 | THRB (0.59) | MEN1KMT2AKCNJ1KCNH2THRB | |
| SCHEMBL6627983 | 0.74 | HRH3 (0.71) | SIGMAR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2702059-A1 | NOVEL COMPOUND USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | Galapagos N.V. (BE) | 2014-03-05 | — | — | EP | disclosed |
| WO-2012146659-A1 | NOVEL COMPOUND USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2012-11-01 | — | — | WO | disclosed |