Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3664165 | 0.94 | KMT2A (0.52) | KMT2AHDAC6LMNAALDH1A1HTT | |
| SCHEMBL3659938 | 0.92 | KMT2A (0.61) | KMT2AALDH1A1MAPTMEN1USP2 | |
| SCHEMBL4121157 | 0.88 | KMT2A (0.55) | KMT2AHDAC6LMNAALDH1A1HTT | |
| SCHEMBL3662924 | 0.85 | KMT2A (0.51) | KMT2AHDAC6LMNAALDH1A1HTT | |
| SCHEMBL3663231 | 0.85 | HDAC6 (0.58) | KMT2AHDAC6LMNAALDH1A1HTT | |
| SCHEMBL3660389 | 0.85 | HDAC6 (0.58) | KMT2AHDAC6LMNAALDH1A1HTT | |
| SCHEMBL4122445 | 0.84 | KMT2A (0.55) | KMT2AHDAC6LMNAALDH1A1HTT | |
| SCHEMBL3660786 | 0.84 | KMT2A (0.57) | KMT2AHDAC6LMNAALDH1A1HTT | |
| SCHEMBL3659564 | 0.84 | POLB (0.63) | KMT2ALMNAMEN1POLB | |
| SCHEMBL3660710 | 0.82 | KMT2A (0.66) | KMT2AMAPTMEN1USP2CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212314-A1 | IMIDAZOLIDINE-2,4-DIONE (HYDANTOIN) DERIVATIVES USEFUL AS NPY Y2 RECEPTOR MODULATORS | Novartis AG (CH) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009050200-A1 | IMIDAZOLIDINE-2,4-DIONE (HYDANTOIN) DERIVATIVES USEFUL AS NPY Y2 RECEPTOR MODULATORS | NOVARTIS AG (CH) | 2009-04-23 | — | — | WO | disclosed |