Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | TYMS | P04818 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 3/20 | 0.32 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.31 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.31 |
| ▸ | ECE1 | P42892 | 1/20 | 0.31 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13439628 | 0.74 | MAOA (0.56) | KMT2AMAPTRECQLMCL1RXFP1 | |
| SCHEMBL2821364 | 0.74 | MAPT (0.52) | KMT2AMAPTRECQLMCL1RXFP1 | |
| SCHEMBL14939549 | 0.74 | MAPT (0.52) | KMT2AMAPTRECQLMCL1RXFP1 | |
| SCHEMBL11237539 | 0.74 | KMT2A (0.52) | KMT2AMAPTRECQLMCL1RXFP1 | |
| SCHEMBL10672939 | 0.74 | KMT2A (0.52) | KMT2AMAPTRECQLMCL1RXFP1 | |
| SCHEMBL88188 | 0.70 | CES1 (0.52) | KMT2AMAPTRECQLMCL1RXFP1 | |
| SCHEMBL29353628 | 0.70 | CES1 (0.52) | KMT2AMAPTRECQLMCL1RXFP1 | |
| SCHEMBL12338444 | 0.70 | ALDH1A1 (0.59) | KMT2AMAPTRECQLMCL1RXFP1 | |
| SCHEMBL21090481 | 0.69 | MAPT (0.47) | KMT2AMAPTRECQLMCL1RXFP1 | |
| SCHEMBL16521619 | 0.68 | MAPT (0.46) | KMT2AMAPTRECQLMCL1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155680-B1 | INDANONE DERIVATIVES THAT INHIBIT PROLYL HYDROXYLASE | AMGEN INC (US) | 2013-12-04 | — | — | EP | disclosed |
| EP-2155680-A1 | INDANONE DERIVATIVES THAT INHIBIT PROLYL HYDROXYLASE | Amgen, Inc (US) | 2010-02-24 | — | — | EP | disclosed |
| US-7569726-B2 | Indanone derivatives that inhibit prolyl hydroxylase | AMGEN INC. (US) | 2009-08-04 | — | — | US | disclosed |
| US-20090088475-A1 | Indanone derivatives that inhibit prolyl hydroxylase | AMGEN INC. (US) | 2009-04-02 | — | — | US | disclosed |
| WO-2008130508-A1 | INDANONE DERIVATIVES THAT INHIBIT PROLYL HYDROXYLASE | AMGEN INC. (US) | 2008-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088475-A1 | Indanone derivatives that inhibit prolyl hydroxylase | HIF1AN, EGLN3, EGLN2 | KMT2A 1192/4885MAPT 3874/4885RECQL 3446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.