Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HNF4A | P41235 | 2/20 | 0.46 |
| ▸ | GABRP | O00591 | 1/20 | 0.46 |
| ▸ | GABRD | O14764 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11385812 | 0.91 | MAOA (0.63) | MAOARAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL5738370 | 0.80 | MAOA (0.48) | MAOARAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL1750256 | 0.76 | PTPN1 (0.46) | RAB9ANPC1KDM4EALDH1A1LMNA | |
| SCHEMBL1751525 | 0.75 | ALDH1A1 (0.48) | MAOARAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL2340821 | 0.75 | MAPT (0.81) | RAB9ANPC1KDM4EALDH1A1MEN1 | |
| SCHEMBL1750895 | 0.74 | HTT (0.43) | RAB9ANPC1ALDH1A1LMNAL3MBTL1 | |
| Hydrochloric Acid SCHEMBL4026672 | 0.74 | ALDH1A1 (0.47) | MAOARAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL1301907 | 0.74 | MAOA (0.75) | MAOARAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL11093874 | 0.74 | HNF4A (0.60) | MAOARAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL7233246 | 0.74 | HTT (0.51) | MAOARAB9AKDM4EALDH1A1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225205-A1 | ESTER DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.p.A. (IT) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009077068-A9 | ESTER DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMA SPA (IT) | 2009-08-20 | — | — | WO | disclosed |
| WO-2009077068-A1 | ESTER DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-06-25 | — | — | WO | disclosed |