Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 8/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 8/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3667973 | 0.76 | HDAC1 (0.32) | HDAC8 | |
| SCHEMBL3669837 | 0.76 | AURKA (0.32) | IKBKETBK1AURKBCDK2 | |
| SCHEMBL3019050 | 0.76 | KCNH2 (0.46) | — | |
| SCHEMBL3022635 | 0.73 | MTNR1A (0.36) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL3020759 | 0.69 | MTNR1A (0.38) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL3663681 | 0.69 | PDE2A (0.37) | MTNR1AMTNR1BMAPK1CA1CA2 | |
| SCHEMBL3016078 | 0.68 | MTNR1A (0.35) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL3016071 | 0.68 | MTNR1A (0.35) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL3008126 | 0.68 | MTNR1A (0.34) | MTNR1AMTNR1BMAPK1CA1CA2 | |
| SCHEMBL3009533 | 0.66 | MTNR1A (0.36) | MTNR1AMTNR1BMAPK1GRIN2BCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139898-A1 | COMPOUNDS | Glaxo Group Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008128961-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |