Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 2/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
| ▸ | NOS2 | P35228 | 2/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | IKBKE | Q14164 | 6/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3663718 | 0.76 | MTNR1A (0.34) | IKBKETBK1AURKBCDK2 | |
| SCHEMBL3019050 | 0.69 | KCNH2 (0.46) | — | |
| SCHEMBL3667973 | 0.67 | HDAC1 (0.32) | HTTSMN1; SMN2 | |
| SCHEMBL14361905 | 0.61 | KDM4E (0.44) | AURKANOS3NOS1NOS2FPR2 | |
| SCHEMBL4981499 | 0.60 | AURKA (0.40) | AURKANOS3NOS1NOS2IKBKE | |
| SCHEMBL10211617 | 0.57 | KDM4E (0.51) | AURKALMNAHTTSMN1; SMN2NPSR1 | |
| SCHEMBL4065673 | 0.56 | ADRA2A (0.44) | NOS3NOS1NOS2CDK2HTT | |
| SCHEMBL10211161 | 0.55 | KDM4E (0.51) | NOS1AURKBCDK2HTTNPSR1 | |
| SCHEMBL4761258 | 0.54 | EGFR (0.38) | HTT | |
| SCHEMBL29386273 | 0.54 | RAB9A (0.66) | LMNAHTTSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139898-A1 | COMPOUNDS | Glaxo Group Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008128961-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |