Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2777087 | 0.83 | THRB (0.43) | DHODHPTGS2GAAKDM4ETP53 | |
| SCHEMBL2774983 | 0.74 | GPBAR1 (0.47) | DHODHPTGS2GAAKDM4ESMN1; SMN2 | |
| SCHEMBL2473730 | 0.72 | PTGS1 (0.61) | PTGS2GAASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL2775786 | 0.71 | TSHR (0.52) | GAAKDM4ERAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2776718 | 0.70 | TSHR (0.54) | GAAKDM4ERAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2777734 | 0.70 | POLB (0.54) | GAAKDM4ESMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL457305 | 0.69 | GHSR (0.47) | GAAKDM4ETP53RAB9ASMN1; SMN2 | |
| SCHEMBL2470830 | 0.69 | PTGS1 (0.54) | PTGS2GAACYP1A2CYP2C19CYP2C9 | |
| SCHEMBL2775977 | 0.69 | ALDH1A1 (0.50) | PTGS2GAAKDM4ETP53RAB9A | |
| SCHEMBL2776047 | 0.69 | GPBAR1 (0.48) | KDM4ETP53SMN1; SMN2CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227475-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | Fibrogen, Inc. (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073669-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | FIBROGEN, INC. (US) | 2009-06-11 | — | — | WO | disclosed |