Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TLR4 | O00206 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | MT-CO2 | P00403 | 3/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6294299 | 0.84 | MCL1 (0.38) | MCL1MAPTTLR4KDM4ESLC18A3 | |
| SCHEMBL11081798 | 0.79 | MCL1 (0.41) | MCL1MAPTTLR4KDM4ENPSR1 | |
| SCHEMBL28007099 | 0.78 | NPC1 (0.43) | MCL1MAPTTLR4SLC18A3LMNA | |
| SCHEMBL11079196 | 0.78 | MCL1 (0.40) | MCL1MAPTKDM4EHAO1ALDH1A1 | |
| SCHEMBL24815345 | 0.75 | DDB1 (0.53) | MCL1MAPTTLR4KDM4ECA1 | |
| SCHEMBL1617179 | 0.75 | CA1 (0.43) | MCL1MAPTTLR4CA1ALDH1A1 | |
| SCHEMBL4132442 | 0.75 | DDB1 (0.53) | MCL1MAPTTLR4KDM4ECA1 | |
| SCHEMBL22566680 | 0.75 | MCL1 (0.41) | MCL1MAPTTLR4KDM4ESLC18A3 | |
| SCHEMBL19479825 | 0.75 | CA1 (0.43) | MCL1MAPTTLR4CA1ALDH1A1 | |
| SCHEMBL10356725 | 0.75 | KDM4E (0.45) | MCL1MAPTTLR4KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231629-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009087127-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-16 | — | — | WO | disclosed |