Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TLR4 | O00206 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3664492 | 0.84 | MCL1 (0.38) | MCL1MAPTTLR4KDM4ECA1 | |
| SCHEMBL11081798 | 0.82 | MCL1 (0.41) | MCL1MAPTTLR4KDM4ESMN1; SMN2 | |
| SCHEMBL11079196 | 0.81 | MCL1 (0.40) | MCL1MAPTKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL11082665 | 0.77 | CREBBP (0.37) | MCL1MAPTKDM4EALDH1A1TP53 | |
| SCHEMBL24815345 | 0.75 | DDB1 (0.53) | MCL1MAPTTLR4KDM4ECA1 | |
| SCHEMBL10356725 | 0.75 | KDM4E (0.45) | MCL1MAPTTLR4KDM4ESMN1; SMN2 | |
| SCHEMBL22566680 | 0.75 | MCL1 (0.41) | MCL1MAPTTLR4KDM4ECA1 | |
| SCHEMBL1617179 | 0.75 | CA1 (0.43) | MCL1MAPTTLR4CA1ALDH1A1 | |
| SCHEMBL4132442 | 0.75 | DDB1 (0.53) | MCL1MAPTTLR4KDM4ECA1 | |
| SCHEMBL19479825 | 0.75 | CA1 (0.43) | MCL1MAPTTLR4CA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890959-B2 | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2005-05-10 | — | — | US | claimed |
| EP-1246791-B1 | AMINOMETHYL-PHENYL-CYCLOHEXANONE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2004-10-27 | — | — | EP | claimed |
| CN-1437575-A | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2003-08-20 | — | — | CN | claimed |
| US-20030096811-A1 | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2003-05-22 | — | — | US | claimed |
| CN-100467441-C | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2009-03-11 | — | — | CN | disclosed |
| CN-100467441-C | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2009-03-11 | — | — | CN | disclosed |
| CN-100467441-C | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2009-03-11 | — | — | CN | disclosed |
| US-6890959-B2 | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2005-05-10 | — | — | US | disclosed |
| US-6890959-B2 | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2005-05-10 | — | — | US | disclosed |
| US-6890959-B2 | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2005-05-10 | — | — | US | disclosed |
| EP-1246791-B1 | AMINOMETHYL-PHENYL-CYCLOHEXANONE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2004-10-27 | — | — | EP | disclosed |
| CN-1437575-A | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2003-08-20 | — | — | CN | disclosed |
| CN-1437576-A | Substituted aminomethyl-phenyl-cyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2003-08-20 | — | — | CN | disclosed |
| CN-1437575-A | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2003-08-20 | — | — | CN | disclosed |
| US-20030096811-A1 | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2003-05-22 | — | — | US | disclosed |
| US-20030096811-A1 | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2003-05-22 | — | — | US | disclosed |
| US-20030096811-A1 | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2003-05-22 | — | — | US | disclosed |
| EP-1246791-A2 | AMINOMETHYL-PHENYL-CYCLOHEXANONE DERIVATIVES | Grünenthal GmbH (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001049651-A3 | AMINOMETHYL-PHENYL-CYCLOHEXANONE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2002-05-23 | — | — | WO | disclosed |
| WO-2001049651-A2 | AMINOMETHYL-PHENYL-CYCLOHEXANONE DERIVATIVES | Grünenthal GmbH (DE) | 2001-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030096811-A1 | Aminomethyl-phenyl-cyclohexanone derivatives | CYP2J2, CYP2E1, CYP2D6 | MCL1 3024/4885MAPT 1382/4885TLR4 2316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.