Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | KCNT2 | Q6UVM3 | 1/20 | 0.33 |
| ▸ | FABP1 | P07148 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | CNR1 | P21554 | 2/20 | 0.31 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.31 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL965994 | 0.71 | CALCA (0.41) | USP2LMNAKMT2AMAPTNPC1 | |
| SCHEMBL965834 | 0.69 | NPC1 (0.44) | MEN1KMT2ACNR2CNR1NPC1 | |
| SCHEMBL966876 | 0.68 | SMN1; SMN2 (0.37) | USP2LMNACNR2MAPTNPC1 | |
| Hydrochloric Acid SCHEMBL967476 | 0.68 | NPC1 (0.43) | MEN1KMT2ACNR2CNR1NPC1 | |
| SCHEMBL13118257 | 0.65 | PTGDR2 (0.36) | USP2LMNAHCRTR1ALDH1A1PTGDR2 | |
| SCHEMBL966162 | 0.60 | NPC1 (0.56) | MEN1KMT2ANPC1ALDH1A1RAB9A | |
| SCHEMBL968379 | 0.59 | CALCA (0.41) | LMNAMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL966079 | 0.58 | MMP2 (0.39) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL965895 | 0.57 | SMN1; SMN2 (0.41) | USP2LMNAMEN1KMT2AMAPT | |
| SCHEMBL966750 | 0.57 | CALCA (0.40) | LMNAKMT2ACNR2MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7812016-B2 | Naphthyridine integrase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2010-10-12 | — | — | US | disclosed |
| US-20070142365-A1 | Naphthyridine integrase inhibitors | GSK LLC | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142365-A1 | Naphthyridine integrase inhibitors | PCNA, SAMHD1, NTPCR | USP2 4486/4885KCNT2 4431/4885FABP1 3534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.