Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 6/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL675381 | 0.84 | MAPT (0.58) | ALDH1A1MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL674811 | 0.81 | ALDH1A1 (0.55) | ALDH1A1MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL675108 | 0.80 | CA1 (0.46) | ALDH1A1MAPTRAB9ANPC1KMT2A | |
| SCHEMBL13464069 | 0.79 | ALDH1A1 (0.49) | ALDH1A1MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL675624 | 0.77 | ALDH1A1 (0.49) | ALDH1A1MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL16241842 | 0.76 | GCGR (0.63) | ALDH1A1MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL3665386 | 0.76 | MAPT (0.39) | ALDH1A1MAPTRAB9AKMT2AHPGD | |
| SCHEMBL675067 | 0.76 | ALPL (0.58) | ALDH1A1MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL676048 | 0.76 | GSK3B (0.41) | ALDH1A1MAPTSMN1; SMN2RAB9AKMT2A | |
| SCHEMBL3665281 | 0.76 | KDM4E (0.39) | ALDH1A1KMT2AHPGDMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895744-B2 | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2014-11-25 | — | — | US | disclosed |
| EP-2161271-A1 | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl | Università Degli Studi Di Milano - Bicocca (IT) | 2010-03-10 | — | — | EP | disclosed |