Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 8/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL678686 | 0.90 | TERT (0.35) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL675224 | 0.85 | ALDH1A1 (0.38) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL675928 | 0.83 | KDM4E (0.39) | KDM4EALDH1A1HPGDHSD17B10TLR9 | |
| Diethylamine SCHEMBL3664811 | 0.82 | HDAC3 (0.35) | KDM4EALDH1A1KMT2AMEN1GCGR | |
| SCHEMBL3665277 | 0.82 | MAPT (0.33) | KDM4EALDH1A1HSD17B10TLR8TLR7 | |
| SCHEMBL678859 | 0.82 | KDM4E (0.44) | KDM4EALDH1A1HPGDHSD17B10TLR9 | |
| SCHEMBL3665283 | 0.81 | KIF11 (0.35) | ALDH1A1KMT2AMEN1GCGRHDAC3 | |
| SCHEMBL3668532 | 0.80 | TLR9 (0.42) | KDM4EALDH1A1HPGDHSD17B10TLR9 | |
| SCHEMBL3670189 | 0.80 | PKM (0.40) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL3664810 | 0.78 | MEN1 (0.33) | KDM4EALDH1A1HPGDHSD17B10TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895744-B2 | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2014-11-25 | — | — | US | disclosed |
| EP-2161271-A1 | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl | Università Degli Studi Di Milano - Bicocca (IT) | 2010-03-10 | — | — | EP | disclosed |