Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | QDPR | P09417 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.31 |
| ▸ | GABRE | P78334 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3666855 | 0.84 | HTR2C (0.39) | HTR2CNAMPTQDPRMAPK1SIGMAR1 | |
| SCHEMBL3664875 | 0.82 | HTR2C (0.34) | HTR2CNAMPTQDPRMAPK1HDAC1 | |
| SCHEMBL27233080 | 0.72 | NAMPT (0.33) | HTR2CNAMPTQDPRMAPK1SIGMAR1 | |
| SCHEMBL21045793 | 0.69 | NR1H2 (0.32) | HTR2CNAMPTQDPRMAPK1 | |
| SCHEMBL25385174 | 0.68 | NR1H2 (0.32) | HTR2CNAMPT | |
| SCHEMBL15057744 | 0.68 | GABRP (0.31) | NAMPTGABRPGABRDGABRA1TSHR | |
| SCHEMBL21045666 | 0.68 | QDPR (0.35) | QDPR | |
| SCHEMBL18398429 | 0.68 | ADORA1 (0.31) | — | |
| SCHEMBL30493347 | 0.66 | PDK4 (0.45) | NAMPT | |
| SCHEMBL3666130 | 0.65 | ALDH1A1 (0.33) | MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242756-A2 | PYRROLOPYRIMIDINES AND PYRROLOPYRIDINES | Novartis AG (CH) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009087225-A2 | PYRROLOPYRIMIDINES AND PYRROLOPYRIDINES | NOVARTIS AG (CH) | 2009-07-16 | — | — | WO | disclosed |