Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.37 |
| ▸ | EGFR | P00533 | 5/20 | 0.34 |
| ▸ | LCK | P06239 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3664919 | 0.88 | BACE1 (0.36) | BACE1BACE2EGFRLCKPIK3CA | |
| SCHEMBL3667380 | 0.78 | MAPK8 (0.33) | BACE1BACE2EGFRPIK3CA | |
| SCHEMBL3025404 | 0.77 | KDM4C (0.40) | — | |
| SCHEMBL3667381 | 0.76 | KDM4C (0.35) | BACE1BACE2 | |
| SCHEMBL2947601 | 0.70 | NR4A1 (0.56) | — | |
| SCHEMBL15825116 | 0.69 | BRD4 (0.38) | HRH2HRH3DRD2DRD1 | |
| SCHEMBL30931435 | 0.69 | BRD4 (0.38) | HRH2HRH3DRD2DRD1 | |
| SCHEMBL6811822 | 0.69 | ALDH1A1 (0.45) | EGFRLCK | |
| SCHEMBL12891719 | 0.68 | DRD2 (0.40) | HRH2HRH3DRD2DRD1 | |
| SCHEMBL2267169 | 0.68 | NPY5R (0.44) | BACE1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139898-A1 | COMPOUNDS | Glaxo Group Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008128961-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |