Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 5/20 | 0.59 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.59 |
| ▸ | MMP13 | P45452 | 3/20 | 0.59 |
| ▸ | MMP2 | P08253 | 2/20 | 0.59 |
| ▸ | MMP14 | P50281 | 2/20 | 0.59 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.54 |
| ▸ | MMP1 | P03956 | 8/20 | 0.53 |
| ▸ | ADAMTS7 | Q9UKP4 | 3/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.51 |
| ▸ | ADAMTS1 | Q9UHI8 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | TNF | P01375 | 1/20 | 0.51 |
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14890261 | 0.88 | NR4A2 (0.64) | ADAMTS5ADAMTS4MMP13MMP2MMP14 | |
| SCHEMBL14890039 | 0.88 | MAOB (0.67) | SCN9ASCN5AMMP1ADAM17MAOB | |
| SCHEMBL14890368 | 0.86 | SCN9A (0.54) | SCN9ASCN5AMMP1MAOB | |
| SCHEMBL14890410 | 0.84 | SCN9A (0.57) | SCN9ASCN5AMMP1ADAM17MAOB | |
| SCHEMBL364245 | 0.83 | MAOA (0.65) | SCN9ASCN5AMMP1ADAM17MAOB | |
| SCHEMBL366136 | 0.83 | SCN9A (0.49) | SCN9ASCN5ANR4A2EPHX2NR1H4 | |
| SCHEMBL363727 | 0.82 | SCN9A (0.64) | SCN9ASCN5ANR4A2 | |
| SCHEMBL10397867 | 0.82 | L3MBTL1 (0.58) | ADAMTS5ADAMTS4MMP13MMP2MMP14 | |
| SCHEMBL365034 | 0.81 | SCN9A (0.54) | ADAMTS4MMP13SCN9ASCN5AMMP1 | |
| SCHEMBL366812 | 0.80 | MAOB (0.63) | ADAMTS4MMP13MMP2MMP14SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096500-B2 | Acyl sulfonamide compounds | PFIZER LIMITED (GB) | 2015-08-04 | — | — | US | disclosed |
| EP-2593428-B1 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | PFIZER LTD (GB) | 2014-11-19 | — | — | EP | disclosed |
| EP-2593428-A2 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | Pfizer Limited (GB) | 2013-05-22 | — | — | EP | disclosed |
| US-20130109701-A1 | Chemical Compounds | PFIZER LIMITED (GB) | 2013-05-02 | — | — | US | disclosed |
| WO-2012007868-A2 | CHEMICAL COMPOUNDS | PFIZER LIMITED (GB) | 2012-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109701-A1 | Chemical Compounds | SCN1A, SCN1B, SCN7A | ADAMTS5 3274/4885ADAMTS4 4151/4885MMP13 4508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.