Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3195746 | 0.78 | SMN1; SMN2 (0.42) | LMNAHPGDSMN1; SMN2KMT2A | |
| SCHEMBL3633479 | 0.74 | PAX8 (0.44) | ALDH1A1DPP4 | |
| SCHEMBL626155 | 0.68 | AKR1C3 (0.67) | ALDH1A1LMNAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL15524433 | 0.66 | SLC18A3 (0.50) | ALDH1A1LMNACA1CA2GAA | |
| Urea SCHEMBL27805729 | 0.66 | TSHR (0.74) | ALDH1A1LMNATSHRCA12CA1 | |
| SCHEMBL1966806 | 0.65 | POLB (0.47) | ALDH1A1TSHRKMT2A | |
| SCHEMBL14813594 | 0.65 | MAOA (0.41) | ALDH1A1TSHRGAAHPGDMAPT | |
| SCHEMBL16649636 | 0.65 | MAOA (0.41) | ALDH1A1GAAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL3373977 | 0.65 | AKR1C3 (0.45) | ALDH1A1LMNAMAPTSLC18A3SMN1; SMN2 | |
| SCHEMBL3370958 | 0.65 | AKR1C3 (0.45) | ALDH1A1LMNAMAPTSLC18A3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142505-A1 | SULFONAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF | Pfizer, Inc. (US) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008120093-A1 | SULFONAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF | PFIZER INC. (US) | 2008-10-09 | — | — | WO | disclosed |