Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | TDO2 | P48775 | 2/20 | 0.46 |
| ▸ | POLR1A | O95602 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ECE1 | P42892 | 1/20 | 0.42 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365238 | 0.93 | EGFR (0.53) | EGFRSRCACSS2IDO1TDO2 | |
| SCHEMBL361356 | 0.89 | EGFR (0.47) | EGFRSRCACSS2IDO1TDO2 | |
| Potassium Ion SCHEMBL364976 | 0.89 | EGFR (0.47) | EGFRSRCACSS2IDO1TDO2 | |
| SCHEMBL364861 | 0.87 | EGFR (0.51) | EGFRSRCACSS2IDO1TDO2 | |
| SCHEMBL366295 | 0.87 | ALDH1A1 (0.45) | EGFRSRCACSS2IDO1TDO2 | |
| SCHEMBL31060260 | 0.86 | KDM4E (0.45) | ACSS2TP53LMNAHPGDKDM4E | |
| SCHEMBL365908 | 0.86 | KDM4E (0.45) | ACSS2TP53LMNAHPGDKDM4E | |
| SCHEMBL365665 | 0.86 | HPGD (0.50) | ACSS2TP53HPGDKDM4EALDH1A1 | |
| SCHEMBL366536 | 0.82 | EGFR (0.53) | EGFRSRCACSS2IDO1TDO2 | |
| SCHEMBL366370 | 0.81 | EGFR (0.43) | EGFRSRCACSS2IDO1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |