Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31060260 | 1.00 | KDM4E (0.45) | KDM4EHPGDALDH1A1HTTPOLB | |
| Potassium Ion SCHEMBL367740 | 0.88 | KDM4E (0.44) | KDM4EHPGDALDH1A1HTTPOLB | |
| SCHEMBL365749 | 0.87 | KDM4E (0.45) | KDM4EHPGDALDH1A1HTTPOLB | |
| SCHEMBL365665 | 0.87 | HPGD (0.50) | KDM4EHPGDALDH1A1HTTNPC1 | |
| SCHEMBL366535 | 0.86 | EGFR (0.48) | KDM4EHPGDALDH1A1ACSS2MAPT | |
| SCHEMBL366370 | 0.83 | EGFR (0.43) | KDM4EALDH1A1ACSS2MAPTMEN1 | |
| SCHEMBL365934 | 0.82 | KDM4E (0.45) | KDM4EHPGDALDH1A1HTTMAPT | |
| SCHEMBL366389 | 0.81 | ALDH1A1 (0.44) | KDM4EHPGDALDH1A1HTTPOLB | |
| SCHEMBL365909 | 0.81 | LMNA (0.45) | KDM4EHPGDALDH1A1HTTPOLB | |
| SCHEMBL366810 | 0.79 | PTGS2 (0.45) | KDM4EALDH1A1POLBSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |