SCHEMBL3665372

SCHEMBL3665372

O=C(CCl)C1=NOC(c2cccc(I)c2)C1

nearest known ligand 0.35

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PPARG P37231 4/20 0.35
PPARA Q07869 3/20 0.35
TSHR P16473 1/20 0.33
SLC6A2 P23975 1/20 0.32
SLC6A4 P31645 1/20 0.32
SLC6A3 Q01959 1/20 0.32
PTPN1 P18031 1/20 0.32
TEAD1 P28347 1/20 0.32
PARP1 P09874 1/20 0.31
SCN9A Q15858 1/20 0.31
SIGMAR1 Q99720 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1979983 0.84 TSHR (0.47) PPARGPPARATSHRPTPN1SCN9A
SCHEMBL18010262 0.77 GSK3B (0.42) PPARGPPARATSHRSLC6A2SLC6A4
SCHEMBL564213 0.75 POLB (0.35) TSHR
SCHEMBL27995744 0.70 TSHR (0.50) PPARGPPARATSHRPTPN1
SCHEMBL3689235 0.70 TSHR (0.47) PPARGPPARATSHRPTPN1SCN9A
SCHEMBL19270341 0.70 TSHR (0.50) PPARGPPARATSHRPTPN1
SCHEMBL3680890 0.70 TSHR (0.47) PPARGPPARATSHRPTPN1SCN9A
SCHEMBL23531448 0.69 LMNA (0.36)
SCHEMBL3724306 0.69 BRD4 (0.36)
SCHEMBL3665376 0.69 TEAD1 (0.32) PPARGPPARATSHRTEAD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100286147-A1 FUNGICIDAL AMIDES E.I. DUPONT DE NEMOURS AND COMPANY (US) 2010-11-11 US disclosed
EP-2238133-A2 FUNGICIDAL AMIDES E. I. du Pont de Nemours and Company (US) 2010-10-13 EP disclosed
WO-2009094407-A2 FUNGICIDAL AMIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2009-07-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100286147-A1 FUNGICIDAL AMIDES NAT1, NOX1, CBR1 PPARG 2150/4885PPARA 2698/4885TSHR 3362/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.