Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | YAP1 | P46937 | 1/20 | 0.38 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 6/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18010262 | 0.87 | GSK3B (0.42) | TSHRALDH1A1MAPK1GSK3BHIF1A | |
| SCHEMBL3680890 | 0.85 | TSHR (0.47) | TSHRALDH1A1GSK3BPTPN1PPARG | |
| SCHEMBL27995744 | 0.85 | TSHR (0.50) | TSHRPTPN1PPARGPPARASMN1; SMN2 | |
| SCHEMBL19270341 | 0.85 | TSHR (0.50) | TSHRPTPN1PPARGPPARASMN1; SMN2 | |
| SCHEMBL3689235 | 0.85 | TSHR (0.47) | TSHRALDH1A1GSK3BPTPN1PPARG | |
| SCHEMBL3665372 | 0.84 | PPARG (0.35) | TSHRPTPN1PPARGPPARASCN9A | |
| SCHEMBL3679687 | 0.82 | TSHR (0.57) | TSHRALDH1A1PTPN1PPARGPPARA | |
| SCHEMBL167443 | 0.82 | TSHR (0.57) | TSHRALDH1A1PTPN1PPARGPPARA | |
| SCHEMBL3724306 | 0.81 | BRD4 (0.36) | ALDH1A1TRPA1MAPK1GSK3BHIF1A | |
| SCHEMBL12906739 | 0.80 | TSHR (0.50) | TSHRALDH1A1PTPN1PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10604495-B2 | Process for preparing substituted phenylisoxazoline derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2020-03-31 | — | — | US | disclosed |
| EP-3265446-B1 | PROCESS FOR PREPARING SUBSTITUTED PHENYLISOXAZOLINE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2019-08-14 | — | — | EP | disclosed |
| EP-3239137-B1 | (5R)-4,5-DIHYDRO-ISOXAZOLE DERIVATIVES AS WELL AS 1-(2-CHLOROACETYL)-4-PIPERIDINE-CARBONITRILE AND -CARBOXAMIDE DERIVATIVES AS INTERMEDIATES IN THE PREPARATION OF E.G. 4-[4-[(5R)-4,5-DIHYDRO-ISOXAZOL-3-YL]-THIAZOL-2-YL]-PIPERIDINE DERIVATIVES AS FUNGICIDES FOR CROP PROTECTION | DU PONT (US) | 2019-02-13 | — | — | EP | disclosed |
| US-10189799-B2 | Process for preparing substituted phenylisoxazoline derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-01-29 | — | — | US | disclosed |
| US-20190016691-A1 | PROCESS FOR PREPARING SUBSTITUTED PHENYLISOXAZOLINE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-01-17 | — | — | US | disclosed |
| US-9920030-B2 | Fungicidal azocyclic amides | E I DU PONT DE NEMOURS AND COMPANY (US) | 2018-03-20 | — | — | US | disclosed |
| US-20180030002-A1 | Process for preparing substituted phenylisoxazoline derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-02-01 | — | — | US | disclosed |
| US-20180030002-A1 | Process for preparing substituted phenylisoxazoline derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-02-01 | — | — | US | disclosed |
| EP-3239145-A1 | 1-[2-[3,5-SUBSTITUTED-1H-PYRAZOL-1-YL]ACETYL]-4-PIPERIDINE-CARBONITRILE AND -CARBOTHIAMIDE DERIVATIVES AS INTERMEDIATES IN THE PREPARATION OF FUNGICIDES FOR CROP PROTECTION | E. I. du Pont de Nemours and Company (US) | 2017-11-01 | — | — | EP | disclosed |
| EP-3239137-A1 | (5R)-4,5-DIHYDRO-ISOXAZOLE DERIVATIVES AS WELL AS 1-(2-CHLOROACETYL)-4-PIPERIDINE-CARBONITRILE AND -CARBOXAMIDE DERIVATIVES AS INTERMEDIATES IN THE PREPARATION OF E.G. 4-[4-[(5R)-4,5-DIHYDRO-ISOXAZOL-3-YL]-THIAZOL-2-YL]-PIPERIDINE DERIVATIVES AS FUNGICIDES FOR CROP PROTECTION | E. I. du Pont de Nemours and Company (US) | 2017-11-01 | — | — | EP | disclosed |
| US-20130045948-A1 | AZOCYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | E I DU PONT DE NEMOURS AND COMPANY (US) | 2013-02-21 | — | — | US | disclosed |
| EP-2509978-A1 | AZOCYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | E.I. Du Pont De Nemours And Company (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011072207-A1 | AZOCYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-06-16 | — | — | WO | disclosed |
| US-20100240619-A1 | FUNGICIDAL MIXTURES | CORTEVA AGRISCIENCE LLC | 2010-09-23 | — | — | US | disclosed |
| EP-2187748-A2 | FUNGICIDAL COMPOUNDS AND MIXTURES | E. I. du Pont de Nemours and Company (US) | 2010-05-26 | — | — | EP | disclosed |
| US-20090156592-A1 | Fungicidal Azocyclic Amides | E.I. DU PONT DE NEMOURS AND COMPANY (DE) | 2009-06-18 | — | — | US | disclosed |
| WO-2009055514-A2 | FUNGICIDAL MIXTURES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-04-30 | — | — | WO | disclosed |
| EP-2049111-A2 | FUNGICIDAL AZOCYCLIC AMIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008013925-A2 | FUNGICIDAL AZOCYCLIC AMIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-01-31 | — | — | WO | disclosed |
| WO-2008013622-A2 | FUNGICIDAL AZOCYCLIC AMIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10189799-B2 | Process for preparing substituted phenylisoxazoline derivatives | CYP3A7, CYP3A4, CYP4X1 | TSHR 2285/4885ALDH1A1 1036/4885TRPA1 3335/4885 |
| US-20130045948-A1 | AZOCYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | FAAH, FAAH2, NCEH1 | TSHR 2095/4885ALDH1A1 386/4885TRPA1 2791/4885 |
| US-10604495-B2 | Process for preparing substituted phenylisoxazoline derivatives | CYP3A7, CYP3A4, CYP4X1 | TSHR 2285/4885ALDH1A1 1036/4885TRPA1 3335/4885 |
| US-20190016691-A1 | PROCESS FOR PREPARING SUBSTITUTED PHENYLISOXAZOLINE DERIVATIVES | CYP3A7, CYP3A4, CYP4X1 | TSHR 2285/4885ALDH1A1 1036/4885TRPA1 3335/4885 |
| US-20100240619-A1 | FUNGICIDAL MIXTURES | CYP1B1, CYP1A1, NOX1 | TSHR 2769/4885ALDH1A1 440/4885TRPA1 1760/4885 |
| US-20090156592-A1 | Fungicidal Azocyclic Amides | ARG1, NAT1, CHRM1 | TSHR 3187/4885ALDH1A1 999/4885TRPA1 3280/4885 |
| US-20180030002-A1 | Process for preparing substituted phenylisoxazoline derivatives | CYP3A7, CYP3A4, CYP4X1 | TSHR 2285/4885ALDH1A1 1036/4885TRPA1 3335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.