SCHEMBL3665375

SCHEMBL3665375

c1ccc(Pc2ccccc2-c2ccccc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.41
HSD17B10 Q99714 2/20 0.41
BCL2L1 Q07817 2/20 0.41
HPGD P15428 1/20 0.41
CYP2A6 P11509 1/20 0.41
MAPK1 P28482 1/20 0.41
BACE1 P56817 1/20 0.37
DPP4 P27487 1/20 0.37
HDAC4 P56524 1/20 0.35
HDAC2 Q92769 1/20 0.35
HDAC8 Q9BY41 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
TDP1 Q9NUW8 1/20 0.34
BCAT2 O15382 1/20 0.34
PLK4 O00444 1/20 0.34
MAPK9 P45984 1/20 0.34
LIMK1 P53667 1/20 0.34
CLK4 Q9HAZ1 1/20 0.34
AKT3 Q9Y243 1/20 0.34
NISCH Q9Y2I1 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dimethylamine SCHEMBL27476228 0.92 ALDH1A1 (0.35) ALDH1A1HSD17B10BCL2L1HPGDCYP2A6
SCHEMBL30810802 0.87 ALDH1A1 (0.46) ALDH1A1HSD17B10BCL2L1HPGDCYP2A6
SCHEMBL5531704 0.87 ALDH1A1 (0.46) ALDH1A1HSD17B10BCL2L1HPGDCYP2A6
SCHEMBL4061116 0.87 CA12 (0.32) TDP1
SCHEMBL28386630 0.85 ALDH1A1 (0.44) ALDH1A1HSD17B10BCL2L1HPGDCYP2A6
SCHEMBL1304679 0.85 ALDH1A1 (0.44) ALDH1A1HSD17B10BCL2L1HPGDCYP2A6
Hydrochloric Acid SCHEMBL28378153 0.85 ALDH1A1 (0.44) ALDH1A1HSD17B10BCL2L1HPGDCYP2A6
SCHEMBL29511215 0.83 HNF4A (0.36) ALDH1A1HSD17B10BCL2L1HPGDCYP2A6
Propane SCHEMBL27674093 0.79 DPP4 (0.40) ALDH1A1HSD17B10BCL2L1HPGDCYP2A6
SCHEMBL288549 0.79 CA1 (0.37) ALDH1A1BCL2L1TDP1MMP3TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2139905-A2 CHIRAL DIPHOSPINES, METHODS FOR THEIR PREPARATION, TRANSITION METAL COMPLEXES COMPRISING THEM AND USE IN CHIRAL SYNTHESIS Celtic Catalysts Limited (IE) 2010-01-06 EP disclosed
WO-2008117054-A2 CHIRAL DIPHOSPHINES, METHODS FOR THEIR PREPARATION, TRANSITION METAL COMPLEXES COMPRISING THEM AND USE IN CHIRAL SYNTHESIS CELTIC CATALYSTS LIMITED (IE) 2008-10-02 WO disclosed
CN-1220667-C Organic compound and method for producing the same EXXON CHEMICAL PATENTS INC (US) 2005-09-28 CN disclosed
CN-1175941-A Organic compound and method for producing the same EXXON CHEMICAL PATENTS INC (US) 1998-03-11 CN disclosed
US-4188274-A DECARBOXYLATION STANDARD OIL COMPANY (INDIANA) (US) 1980-02-12 US disclosed
US-4174447-A SILVER SALTS OF CARBOXY ACIDS STANDARD OIL COMPANY (INDIANA) (US) 1979-11-13 US disclosed