Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 4/20 | 0.33 |
| ▸ | NOS2 | P35228 | 4/20 | 0.33 |
| ▸ | NOS1 | P29475 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3190363 | 0.83 | UHRF1 (0.42) | UHRF1NOS3NOS2NOS1CYP3A4 | |
| SCHEMBL3169248 | 0.81 | UHRF1 (0.41) | UHRF1NOS3NOS2NOS1CYP3A4 | |
| SCHEMBL142309 | 0.78 | NOS3 (0.42) | UHRF1NOS3NOS2NOS1CYP3A4 | |
| SCHEMBL30470000 | 0.78 | NOS3 (0.42) | UHRF1NOS3NOS2NOS1CYP3A4 | |
| SCHEMBL24843657 | 0.77 | UHRF1 (0.38) | UHRF1NOS3NOS2NOS1KDM4E | |
| SCHEMBL9939737 | 0.77 | LMNA (0.44) | UHRF1NOS3NOS2NOS1KDM4E | |
| SCHEMBL9938081 | 0.77 | UHRF1 (0.38) | UHRF1NOS3NOS2NOS1KDM4E | |
| Hydrochloric Acid SCHEMBL6197993 | 0.76 | NOS3 (0.41) | UHRF1NOS3NOS2NOS1CYP3A4 | |
| SCHEMBL12266514 | 0.74 | UHRF1 (0.44) | UHRF1NOS3NOS2NOS1KDM4E | |
| SCHEMBL31093725 | 0.74 | UHRF1 (0.39) | UHRF1NOS3NOS2NOS1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101981031-A | Tricyclic compounds having corticotropin-releasing factor antagonistic activity and pharmaceutical compositions containing them | TAKEDA PHARMACEUTICAL | 2011-02-23 | — | — | CN | disclosed |
| EP-2240485-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Takeda Pharmaceutical Company Limited (JP) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009093747-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-07-30 | — | — | WO | disclosed |
| US-6225334-B1 | AS PESTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-05-01 | — | — | US | disclosed |
| EP-0517589-B1 | Tachykinin derivatives, their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1996-12-27 | — | — | EP | disclosed |
| US-5317014-A | Analgesics, antiinflammatory agents, antagonist, antiallergens or gastrointestinal disorders | ADIR ET COMPAGNIE (FR) | 1994-05-31 | — | — | US | disclosed |
| EP-0517589-A2 | Tachykinin derivatives, their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-12-09 | — | — | EP | disclosed |