Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPY1R | P25929 | 1/20 | 0.45 |
| ▸ | NPY2R | P49146 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1987646 | 0.94 | LMNA (0.54) | LMNAHTR1DHTR1BGAASMN1; SMN2 | |
| SCHEMBL1985494 | 0.81 | LMNA (0.41) | LMNAHTR1DHTR1BGAASMN1; SMN2 | |
| SCHEMBL1988447 | 0.75 | ROCK2 (0.55) | LMNAHTR1BGAAKDM4EL3MBTL1 | |
| SCHEMBL1992407 | 0.74 | LMNA (0.49) | LMNAHTR1DHTR1BGAASMN1; SMN2 | |
| SCHEMBL3665879 | 0.74 | LMNA (0.46) | LMNAHTR1DHTR1BGAASMN1; SMN2 | |
| SCHEMBL135868 | 0.73 | CARM1 (0.64) | LMNASMN1; SMN2TSHRKDM4ETMEM97 | |
| SCHEMBL3888894 | 0.73 | LMNA (0.86) | LMNAHTR1DHTR1BGAASMN1; SMN2 | |
| SCHEMBL2053847 | 0.73 | KDM4E (0.57) | LMNAHTR1DHTR1BGAASMN1; SMN2 | |
| SCHEMBL3714084 | 0.72 | ROCK2 (0.71) | LMNAHTR1DHTR1BTSHR | |
| Hydrochloric Acid SCHEMBL6509438 | 0.72 | CARM1 (0.62) | LMNASMN1; SMN2TSHRKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234618-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079008-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |