Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1987646 | 0.74 | LMNA (0.54) | LMNAHTR1DHTR1BGAASMN1; SMN2 | |
| SCHEMBL3665876 | 0.74 | LMNA (0.49) | LMNAHTR1DHTR1BGAASMN1; SMN2 | |
| SCHEMBL3888894 | 0.71 | LMNA (0.86) | LMNAHTR1DHTR1BGAASMN1; SMN2 | |
| SCHEMBL1992407 | 0.70 | LMNA (0.49) | LMNAHTR1DHTR1BGAASMN1; SMN2 | |
| SCHEMBL6351462 | 0.65 | AKR1C2 (0.58) | SMN1; SMN2TSHRATMNPC1MCHR1 | |
| SCHEMBL781749 | 0.65 | ADRA2B (0.46) | LMNAGAAKDM4ETSHRATM | |
| SCHEMBL8391031 | 0.65 | HTR1D (0.63) | LMNAHTR1DHTR1BTSHRATM | |
| Hydrochloric Acid SCHEMBL8704830 | 0.64 | HTR1D (0.62) | LMNAHTR1DHTR1BTSHRATM | |
| SCHEMBL8487152 | 0.64 | HTR1D (0.62) | LMNAHTR1DHTR1BSMN1; SMN2TSHR | |
| SCHEMBL17682060 | 0.63 | TSHR (0.81) | HTR1DHTR1BKDM4ETSHRATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234618-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079008-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |