Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | CFB | P00751 | 1/20 | 0.41 |
| ▸ | PPID | Q08752 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048052 | 0.95 | RIPK1 (0.49) | RIPK1CYP19A1EPHX2HSD11B1PPID | |
| SCHEMBL27574946 | 0.82 | RIPK1 (0.62) | RIPK1EPHX2HSD11B1HSP90AA1HSP90AB1 | |
| SCHEMBL27574934 | 0.82 | RIPK1 (0.62) | RIPK1EPHX2HSD11B1HSP90AA1HSP90AB1 | |
| SCHEMBL216202 | 0.82 | RIPK1 (0.62) | RIPK1EPHX2HSD11B1HSP90AA1HSP90AB1 | |
| SCHEMBL16891471 | 0.82 | RIPK1 (0.48) | RIPK1CYP19A1EPHX2CFBPPID | |
| SCHEMBL29892279 | 0.81 | CCNC (0.51) | RIPK1HSD11B1SMN1; SMN2 | |
| SCHEMBL27580250 | 0.81 | CCNC (0.51) | RIPK1HSD11B1SMN1; SMN2 | |
| SCHEMBL12478830 | 0.81 | PPID (0.48) | RIPK1EPHX2HSD11B1PPIDHSP90AA1 | |
| SCHEMBL14920930 | 0.81 | HSD11B1 (0.54) | RIPK1HSD11B1SMN1; SMN2HPGD | |
| SCHEMBL1653726 | 0.81 | GPR119 (0.47) | RIPK1TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240028-A1 | ORGANIC COMPOUNDS | Intra-Cellular Therapies, Inc. (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009073210-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC (US) | 2009-06-11 | — | — | WO | disclosed |