Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.46 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | VSIR | Q9H7M9 | 2/20 | 0.36 |
| ▸ | PDCD1LG2 | Q9BQ51 | 3/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3667596 | 0.92 | MEN1 (0.43) | SMN1; SMN2CD274PDCD1MCHR1HRH4 | |
| SCHEMBL3662196 | 0.83 | S1PR1 (0.44) | SMN1; SMN2ALDH1A1S1PR2S1PR1S1PR3 | |
| SCHEMBL3666546 | 0.83 | PRMT6 (0.48) | SMN1; SMN2CD274PDCD1VSIR | |
| SCHEMBL29142174 | 0.81 | CHRM2 (0.38) | SMN1; SMN2CD274PDCD1ALDH1A1TSHR | |
| SCHEMBL3668234 | 0.80 | FFAR1 (0.37) | ALDH1A1S1PR2S1PR1S1PR3 | |
| SCHEMBL3663742 | 0.80 | ADRB2 (0.42) | HRH4HRH3MKNK1MKNK2CHEK1 | |
| SCHEMBL3662222 | 0.79 | MKNK1 (0.53) | TSHRMKNK1MKNK2CHEK1 | |
| SCHEMBL4167973 | 0.77 | PPID (0.38) | SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL3664072 | 0.76 | SCN8A (0.46) | CD274PDCD1VSIRMEN1KMT2A | |
| SCHEMBL21052776 | 0.76 | SMN1; SMN2 (0.62) | SMN1; SMN2CD274PDCD1MCHR1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101970435-B | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG | 2014-07-02 | — | — | CN | claimed |
| US-8314112-B2 | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG (CH) | 2012-11-20 | — | — | US | claimed |
| CN-101970435-A | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG | 2011-02-09 | — | — | CN | claimed |
| EP-2242756-A2 | PYRROLOPYRIMIDINES AND PYRROLOPYRIDINES | Novartis AG (CH) | 2010-10-27 | — | — | EP | claimed |
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | NOVARTIS AG (CH) | 2009-07-16 | — | — | US | claimed |
| WO-2009087225-A2 | PYRROLOPYRIMIDINES AND PYRROLOPYRIDINES | NOVARTIS AG (CH) | 2009-07-16 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | ALK, ACVR1, PTPN4 | SMN1; SMN2 3064/4885CD274 558/4885PDCD1 814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.