Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F12 | P00748 | 5/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 5/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.34 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3637648 | 0.82 | F2 (0.45) | F12F2HTR1ASLC6A2SLC6A4 | |
| SCHEMBL7008464 | 0.81 | F12 (0.47) | F12F2HTR1ASLC6A2SLC6A4 | |
| SCHEMBL2335872 | 0.78 | F12 (0.47) | F12F2 | |
| SCHEMBL30289956 | 0.78 | F12 (0.47) | F12F2 | |
| SCHEMBL22854651 | 0.77 | TBXAS1 (0.47) | ALDH1A1 | |
| SCHEMBL14720083 | 0.77 | TBXAS1 (0.47) | ALDH1A1 | |
| SCHEMBL13231014 | 0.74 | F2 (0.36) | F12F2KDM4EHSD17B10MAP2K1 | |
| SCHEMBL22854881 | 0.74 | P2RX7 (0.53) | — | |
| SCHEMBL22830016 | 0.74 | P2RX7 (0.53) | — | |
| SCHEMBL26569009 | 0.74 | P2RX7 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150544-A2 | MAPK/ERK KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-02-10 | — | — | EP | claimed |
| WO-2008115890-A2 | MAPK/ERK KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-25 | — | — | WO | claimed |
| EP-2150544-A2 | MAPK/ERK KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008115890-A2 | MAPK/ERK KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-25 | — | — | WO | disclosed |