Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2488173 | 0.84 | HTT (0.46) | KMT2APOLBMEN1SMN1; SMN2GAA | |
| SCHEMBL493413 | 0.82 | KMT2A (0.42) | KMT2APOLBMEN1SMN1; SMN2GAA | |
| SCHEMBL2489904 | 0.77 | KMT2A (0.45) | KMT2AMEN1SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL493681 | 0.76 | KMT2A (0.50) | KMT2APOLBSMN1; SMN2ALDH1A1ALPL | |
| SCHEMBL492816 | 0.73 | BDKRB1 (0.36) | KMT2APOLBMEN1GAAALDH1A1 | |
| SCHEMBL493592 | 0.71 | ALDH1A1 (0.37) | KMT2APOLBMEN1GAAALDH1A1 | |
| SCHEMBL492648 | 0.69 | HTR2A (0.34) | KMT2APOLBMEN1GAAALDH1A1 | |
| SCHEMBL493760 | 0.69 | PKM (0.37) | KMT2APOLBMEN1SMN1; SMN2GAA | |
| SCHEMBL644106 | 0.68 | KMT2A (0.48) | KMT2APOLBMEN1SMN1; SMN2GAA | |
| SCHEMBL493266 | 0.68 | BDKRB1 (0.35) | KMT2APOLBMEN1GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | claimed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | claimed |
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | disclosed |