Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPRA | P18433 | 1/20 | 0.36 |
| ▸ | PTPRB | P23467 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | ARG1 | P05089 | 1/20 | 0.35 |
| ▸ | ARG2 | P78540 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22406298 | 0.87 | SMN1; SMN2 (0.44) | SMN1; SMN2HIF1AALDH1A1RECQLMMP8 | |
| SCHEMBL27780467 | 0.86 | ALDH1A1 (0.42) | SMN1; SMN2HIF1AALDH1A1RECQLMMP8 | |
| SCHEMBL8578234 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2HIF1AALDH1A1RECQLMMP8 | |
| SCHEMBL3249147 | 0.79 | TSHR (0.41) | SMN1; SMN2HIF1AALDH1A1RECQLMMP8 | |
| SCHEMBL27457092 | 0.78 | ALDH1A1 (0.47) | SMN1; SMN2HIF1AALDH1A1RECQLMMP8 | |
| SCHEMBL16447676 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2HIF1AALDH1A1RECQLMMP8 | |
| SCHEMBL1040897 | 0.75 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1RECQLKMT2APPARG | |
| SCHEMBL28359788 | 0.75 | CETP (0.41) | CYP3A4MAPTKMT2AARG1ARG2 | |
| SCHEMBL20393963 | 0.74 | LMNA (0.39) | TSHRCYP3A4LMNA | |
| SCHEMBL28289195 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2HIF1AALDH1A1RECQLMMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222338-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. | 2010-09-02 | — | — | US | disclosed |
| US-7745484-B2 | Beta-secretase modulators and methods of use | AMGEN INC. (US) | 2010-06-29 | — | — | US | disclosed |
| US-20070185144-A1 | Beta-secretase modulators and methods of use | AMGEN INC. (US) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222338-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | BACE1, BACE2, APP | SMN1; SMN2 1679/4885HIF1A 3699/4885ALDH1A1 2461/4885 |
| US-20070185144-A1 | Beta-secretase modulators and methods of use | BACE1, BACE2, APP | SMN1; SMN2 1679/4885HIF1A 3699/4885ALDH1A1 2461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.