Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ESRRB | O95718 | 2/20 | 0.41 |
| ▸ | ESRRG | P62508 | 2/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL3666926 | 0.98 | ADRB1 (0.50) | ADRB1AKR1C3MAPTSMN1; SMN2LMNA | |
| Methane SCHEMBL3668794 | 0.87 | LMNA (0.49) | ADRB1AKR1C3MAPTSMN1; SMN2LMNA | |
| SCHEMBL314459 | 0.85 | NPC1 (0.48) | AKR1C3MAPTSMN1; SMN2LMNAGAA | |
| SCHEMBL314179 | 0.85 | AKR1C3 (0.47) | AKR1C3MAPTSMN1; SMN2LMNAGAA | |
| SCHEMBL12788651 | 0.75 | AKR1C3 (0.59) | AKR1C3MAPTSMN1; SMN2LMNAGAA | |
| SCHEMBL23544885 | 0.74 | AKR1C3 (0.58) | AKR1C3MAPTSMN1; SMN2LMNAGAA | |
| SCHEMBL315629 | 0.74 | DRD4 (0.53) | MAPTSMN1; SMN2LMNAGAAALDH1A1 | |
| SCHEMBL315213 | 0.74 | SMN1; SMN2 (0.56) | AKR1C3MAPTSMN1; SMN2LMNAGAA | |
| SCHEMBL314363 | 0.73 | HTR7 (0.53) | MAPTLMNAALDH1A1MEN1KMT2A | |
| Bicarbonate SCHEMBL11620170 | 0.72 | ADRB1 (0.81) | ADRB1AKR1C3MAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234992-A2 | PIPERAZINE DERIVATIVES AND THEIR USE AS LEPTIN RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2010-10-06 | — | — | EP | claimed |
| WO-2009071668-A2 | PIPERAZINE DERIVATIVES AND THEIR USE AS LEPTIN RECEPTOR MODULATORS | BIOVITRUM AB (PUBL) (SE) | 2009-06-11 | — | — | WO | claimed |