Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9771631 | 0.91 | GLA (0.44) | GPR35MEN1KMT2AGLAMAPT | |
| SCHEMBL5878676 | 0.87 | MEN1 (0.51) | MEN1KMT2AGLAMAPTALDH1A1 | |
| SCHEMBL10480222 | 0.84 | GLA (0.40) | KMT2AGLAMAPTALDH1A1KAT2B | |
| Hydrochloric Acid SCHEMBL5065154 | 0.83 | KAT2B (0.44) | GLAMAPTALDH1A1KAT2BTDP1 | |
| SCHEMBL3666022 | 0.82 | GPR35 (0.43) | GPR35TSHRMEN1KMT2AGLA | |
| SCHEMBL29183738 | 0.79 | TSHR (0.52) | GPR35TSHRMEN1KMT2AMAPT | |
| SCHEMBL5481820 | 0.77 | ALDH1A1 (0.45) | TSHRMEN1KMT2AGLAMAPT | |
| SCHEMBL4606975 | 0.76 | MAPT (0.49) | GPR35TSHRMEN1KMT2AGLA | |
| SCHEMBL1653792 | 0.75 | GPR35 (0.49) | GPR35TSHRMEN1KMT2AMAPT | |
| SCHEMBL10896768 | 0.74 | MAPT (0.45) | TSHRMEN1KMT2AGLAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240485-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Takeda Pharmaceutical Company Limited (JP) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009093747-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-07-30 | — | — | WO | disclosed |