Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | CTRC | Q99895 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4872180 | 0.87 | CALM1 (0.52) | CALM1HTR2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL28025161 | 0.81 | CALM1 (0.46) | CALM1HTR2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL31152647 | 0.81 | CALM1 (0.46) | CALM1HTR2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL7192027 | 0.80 | HTR2A (0.54) | CALM1HTR2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL2140999 | 0.80 | HTR2A (0.54) | CALM1HTR2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL28897010 | 0.80 | TAAR1 (0.39) | CYP3A4CYP2D6CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL29940610 | 0.80 | CALM1 (0.55) | CALM1HTR2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9741301 | 0.80 | CALM1 (0.55) | CALM1HTR2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL275838 | 0.80 | CALM1 (0.55) | CALM1HTR2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL24298226 | 0.80 | TSHR (0.52) | SMN1; SMN2TSHRMAPTALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242747-A1 | SUBSTITUTED IMIDAZOLIDINE-2,4-DIONES, METHOD FOR THE PRODUCTION THEREOF, MEDICAMENTS CONTAINING SAID COMPOUNDS AND USE THEREOF | Sanofi-Aventis (FR) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009097997-A1 | SUBSTITUTED IMIDAZOLIDINE-2,4-DIONES, METHOD FOR THE PRODUCTION THEREOF, MEDICAMENTS CONTAINING SAID COMPOUNDS AND USE THEREOF | SANOFI-AVENTIS (FR) | 2009-08-13 | — | — | WO | disclosed |