Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 7/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL390885 | 0.78 | CYP1A2 (1.00) | CYP1A2NPC1ALDH1A1LMNAHSP90AA1 | |
| SCHEMBL390886 | 0.78 | CYP1A2 (1.00) | CYP1A2NPC1ALDH1A1LMNAHSP90AA1 | |
| SCHEMBL13309907 | 0.69 | CYP1A2 (0.45) | CYP1A2NPC1ALDH1A1LMNAHSP90AA1 | |
| SCHEMBL22578238 | 0.67 | CYP1A2 (0.47) | CYP1A2NPC1ALDH1A1LMNAHSP90AA1 | |
| SCHEMBL387105 | 0.64 | SMN1; SMN2 (0.73) | CYP1A2NPC1ALDH1A1LMNAHSP90AA1 | |
| SCHEMBL20597553 | 0.63 | MEN1 (0.46) | CYP1A2NPC1ALDH1A1LMNARAB9A | |
| SCHEMBL25384005 | 0.62 | L3MBTL1 (0.57) | CYP1A2NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL20597903 | 0.62 | CYP1A2 (0.41) | CYP1A2NPC1RAB9ASMN1; SMN2KIF11 | |
| SCHEMBL22578241 | 0.61 | MEN1 (0.51) | ALDH1A1LMNAGAASMN1; SMN2MEN1 | |
| SCHEMBL23609299 | 0.61 | CYP1A2 (0.42) | CYP1A2NPC1ALDH1A1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816364-B2 | GRP119 receptor agonists in methods of increasing bone mass and of treating osteoporosis and other conditions characterized by low bone mass, and combination therapy relating thereto | ARENA PHARMACEUTICALS, INC. (US) | 2010-10-19 | — | — | US | disclosed |
| US-20090270422-A1 | GPR119 receptor agonists in methods of increasing bone mass and of treating osteoporosis and other conditions characterized by low bone mass, and combination therapy relating thereto | ARENA PHARMACEUTICALS, INC. | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270422-A1 | GPR119 receptor agonists in methods of increasing bone mass and of treating osteoporosis and other conditions characterized by low bone mass, and combination therapy relating thereto | GPR119, GLP1R, GPR4 | CYP1A2 2735/4885NPC1 2006/4885ALDH1A1 2608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.