Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 17/20 | 0.53 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.45 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5047611 | 0.84 | HPGDS (0.61) | HPGDS | |
| SCHEMBL61133 | 0.84 | HDAC4 (0.53) | HPGDS | |
| SCHEMBL14784227 | 0.81 | MET (0.41) | — | |
| SCHEMBL14784244 | 0.77 | MET (0.43) | — | |
| SCHEMBL18987769 | 0.75 | HPGDS (0.50) | HPGDS | |
| SCHEMBL30578690 | 0.75 | HPGDS (0.48) | HPGDSCXCR4DPP4DPP7 | |
| SCHEMBL29082338 | 0.75 | HPGDS (0.48) | HPGDSCXCR4DPP4DPP7 | |
| SCHEMBL14784654 | 0.74 | ME3 (0.44) | — | |
| SCHEMBL16194601 | 0.74 | PRKAA2 (0.48) | HPGDS | |
| SCHEMBL19021457 | 0.74 | HPGDS (0.55) | HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231666-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009076631-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-06-18 | — | — | WO | disclosed |