Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 9/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ether SCHEMBL936882 | 0.88 | TSHR (0.48) | TSHRTDP1HPGDALDH1A1TP53 | |
| Ether SCHEMBL1111133 | 0.86 | TSHR (0.48) | TSHRTDP1HPGDALDH1A1TP53 | |
| Propylene Glycol SCHEMBL8605999 | 0.85 | TDP1 (0.41) | TSHRTDP1HPGDALDH1A1HSD17B10 | |
| Propylene Glycol SCHEMBL243614 | 0.85 | TDP1 (0.41) | TSHRTDP1HPGDALDH1A1HSD17B10 | |
| Propylene Glycol SCHEMBL460711 | 0.84 | TDP1 (0.46) | TSHRTDP1ALDH1A1CYP3A4SMN1; SMN2 | |
| Acrylic Acid Ethyl Ester SCHEMBL28810900 | 0.83 | TSHR (0.53) | TSHRTDP1HPGDALDH1A1TP53 | |
| Acrylic Acid Methyl Ester SCHEMBL19888861 | 0.81 | TSHR (0.40) | TSHRTDP1HPGDALDH1A1TP53 | |
| Propylene Glycol SCHEMBL3670673 | 0.81 | THRB (0.47) | TSHRTDP1ALDH1A1THRBCYP3A4 | |
| Ether SCHEMBL11078205 | 0.81 | TSHR (0.62) | TSHRTDP1HPGDALDH1A1TP53 | |
| 2-Ethoxyethanol SCHEMBL11346768 | 0.80 | TSHR (0.55) | TSHRTDP1HPGDALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2218724-B1 | EPOXY GROUP-CONTAINING ORGANOSILOXANE COMPOUND, CURABLE COMPOSITION FOR TRANSFER MATERIAL, AND FINE PATTERN FORMING METHOD USING THE COMPOSITION | SHOWA DENKO KK (JP) | 2015-01-07 | — | — | EP | disclosed |
| US-8604150-B2 | Epoxy group-containing organosiloxane compound, curable composition for transfer materials and method for forming micropattern using the composition | SHOWA DENKO K.K. (JP) | 2013-12-10 | — | — | US | disclosed |
| US-20100258983-A1 | EPOXY GROUP-CONTAINING ORGANOSILOXANE COMPOUND, CURABLE COMPOSITION FOR TRANSFER MATERIALS AND METHOD FOR FORMING MICROPATTERN USING THE COMPOSITION | SHOWA DENKO K.K. (JP) | 2010-10-14 | — | — | US | disclosed |
| EP-2218724-A1 | EPOXY GROUP-CONTAINING ORGANOSILOXANE COMPOUND, CURABLE COMPOSITION FOR TRANSFER MATERIAL, AND FINE PATTERN FORMING METHOD USING THE COMPOSITION | Showa Denko K.K. (JP) | 2010-08-18 | — | — | EP | disclosed |