Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | C1R | P00736 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | FABP3 | P05413 | 1/20 | 0.32 |
| ▸ | FABP4 | P15090 | 1/20 | 0.32 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | TEC | P42680 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2011498 | 0.87 | CRHBP (0.39) | CRHBPCRHR2 | |
| SCHEMBL29447040 | 0.81 | BACE1 (0.50) | BACE1HTR3AHRH4HRH3CYP2A6 | |
| SCHEMBL198060 | 0.81 | BACE1 (0.50) | BACE1HTR3AHRH4HRH3CYP2A6 | |
| SCHEMBL3666214 | 0.73 | BACE1 (0.43) | BACE1HTR3AHRH4TYMSHRH3 | |
| SCHEMBL1598979 | 0.70 | BACE1 (0.39) | BACE1TYMS | |
| SCHEMBL22791436 | 0.70 | HTR3A (0.45) | BACE1HTR3AHRH4TYMSHRH3 | |
| SCHEMBL22951353 | 0.69 | IDO1 (0.38) | BACE1 | |
| SCHEMBL2133059 | 0.67 | NR4A2 (0.54) | BACE1HTR3AHRH3MAPTMAPK1 | |
| SCHEMBL30506415 | 0.67 | NR4A2 (0.54) | BACE1HTR3AHRH3MAPTMAPK1 | |
| SCHEMBL2130719 | 0.66 | BACE1 (0.72) | BACE1TEC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139879-A1 | QUINOLINE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES | AstraZeneca AB (SE) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008114002-A1 | QUINOLINE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES | ASTRAZENECA AB (SE) | 2008-09-25 | — | — | WO | disclosed |