Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2840817 | 0.88 | PKM (0.39) | MAPTHTTALDH1A1GPR35TDP1 | |
| SCHEMBL30594994 | 0.79 | CTSB (0.39) | MAPTHTTLMNAALDH1A1GPR35 | |
| SCHEMBL4839201 | 0.79 | MAPT (0.39) | MAPTHTTLMNAALDH1A1TDP1 | |
| SCHEMBL8033158 | 0.75 | ALDH1A1 (0.43) | MAPTHTTLMNAALDH1A1TDP1 | |
| SCHEMBL891790 | 0.74 | — | — | |
| Sulfuric Acid SCHEMBL27717455 | 0.73 | HTT (0.39) | MAPTHTTLMNAALDH1A1TDP1 | |
| SCHEMBL4519825 | 0.73 | CTSB (0.40) | MAPTHTTLMNAALDH1A1GPR35 | |
| SCHEMBL30594978 | 0.73 | CTSB (0.40) | MAPTHTTLMNAALDH1A1GPR35 | |
| Hydrochloric Acid SCHEMBL2845698 | 0.72 | POLB (0.46) | MAPTHTTLMNAALDH1A1POLB | |
| SCHEMBL8884172 | 0.72 | GRIN2D (0.41) | MAPTHTTLMNAALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240485-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Takeda Pharmaceutical Company Limited (JP) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009093747-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-07-30 | — | — | WO | disclosed |