Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PTGFR | P43088 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2635459 | 0.83 | NPSR1 (0.53) | HPGDALDH1A1NPSR1FAAHKDM1A | |
| SCHEMBL17440956 | 0.81 | ALDH1A1 (0.40) | HPGDALDH1A1NPSR1FAAHMAPT | |
| SCHEMBL4696917 | 0.78 | NPSR1 (0.51) | NPSR1MTNR1AMTNR1B | |
| SCHEMBL17261563 | 0.78 | MEN1 (0.46) | ALDH1A1NPSR1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL7445471 | 0.77 | KEAP1 (0.44) | HPGDALDH1A1NPSR1FAAHKDM1A | |
| SCHEMBL2956236 | 0.76 | MAPK1 (0.40) | HPGDNPSR1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL10708175 | 0.75 | ALDH1A1 (0.66) | HPGDALDH1A1LMNAGRM5 | |
| SCHEMBL7437586 | 0.75 | SMN1; SMN2 (0.47) | HPGDALDH1A1FAAHMAPTSMN1; SMN2 | |
| SCHEMBL2767293 | 0.75 | NPSR1 (0.77) | HPGDALDH1A1NPSR1FAAHMAPT | |
| SCHEMBL901976 | 0.74 | ALDH1A1 (0.46) | HPGDALDH1A1MAPTRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-B1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME (US) | 2012-10-17 | — | — | EP | disclosed |
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |