Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901874 | 0.84 | ASIC3 (0.47) | KDM4ELMNAMMP2MMP9MMP8 | |
| SCHEMBL1755659 | 0.82 | NQO2 (0.46) | KDM4E | |
| SCHEMBL21049906 | 0.76 | AKR1C3 (0.53) | ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL901955 | 0.75 | NPC1 (0.63) | ALDH1A1HPGDNPC1RAB9AHDAC3 | |
| SCHEMBL901872 | 0.75 | KARS1 (0.52) | NPC1RAB9AHIF1A | |
| SCHEMBL12469132 | 0.75 | KARS1 (0.72) | ALDH1A1KDM4ELMNANPC1RAB9A | |
| SCHEMBL901695 | 0.74 | MEN1 (0.38) | ALDH1A1HPGDLMNAMAPTDAGLA | |
| SCHEMBL3669979 | 0.74 | HPGD (0.44) | ALDH1A1HPGDLMNANPC1RAB9A | |
| SCHEMBL3345753 | 0.74 | FAAH (0.53) | NPC1RAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL5374261 | 0.73 | PLAAT3 (0.49) | KDM4EMMP2MMP9HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |