Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.58 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.49 |
| ▸ | CCR3 | P51677 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4215482 | 0.85 | SIGMAR1 (0.58) | SIGMAR1ACKR3CCR3L3MBTL1POLB | |
| SCHEMBL4215479 | 0.85 | SIGMAR1 (0.58) | SIGMAR1ACKR3CCR3L3MBTL1POLB | |
| SCHEMBL3810819 | 0.83 | SIGMAR1 (0.56) | SIGMAR1ACKR3CCR3L3MBTL1POLB | |
| SCHEMBL3810814 | 0.83 | SIGMAR1 (0.56) | SIGMAR1ACKR3CCR3L3MBTL1POLB | |
| SCHEMBL5357866 | 0.79 | LMNA (0.69) | SIGMAR1POLBEPHX2 | |
| SCHEMBL13929427 | 0.78 | SIGMAR1 (0.59) | SIGMAR1CCR3CCR5 | |
| SCHEMBL13951400 | 0.75 | SIGMAR1 (0.69) | SIGMAR1CCR3L3MBTL1CCR5 | |
| SCHEMBL6988819 | 0.75 | SIGMAR1 (0.66) | SIGMAR1EPHX2 | |
| SCHEMBL13929425 | 0.74 | CCR5 (0.68) | SIGMAR1CCR3CCR5 | |
| SCHEMBL5862050 | 0.73 | SIGMAR1 (1.00) | SIGMAR1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173715-A2 | USE OF PIPERIDINE DERIVATIVES AS AGONISTS OF CHEMOKINE RECEPTOR ACTIVITY | Euroscreen S.A. (BE) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009010478-A2 | USE OF PIPERIDINE DERIVATIVES AS AGONISTS OF CHEMOKINE RECEPTOR ACTIVITY | EUROSCREEN S.A. (BE) | 2009-01-22 | — | — | WO | disclosed |