Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3289631 | 0.85 | PGR (0.55) | ARPGREPHX2 | |
| SCHEMBL951252 | 0.85 | GPR119 (0.65) | ARGPR119HRH3 | |
| SCHEMBL216865 | 0.81 | CCR5 (0.44) | ACACBHRH3EPHX2 | |
| SCHEMBL21722970 | 0.80 | BCL2A1 (0.44) | ARGPR119FFAR4ACACBHRH3 | |
| SCHEMBL16483388 | 0.80 | AR (0.48) | ARFFAR4ACACBHRH3MRGPRX4 | |
| SCHEMBL16927539 | 0.79 | FFAR4 (0.42) | ARGPR119FFAR4PIK3CDPIK3CA | |
| SCHEMBL16927540 | 0.79 | FFAR4 (0.42) | ARGPR119FFAR4PIK3CDPIK3CA | |
| SCHEMBL26821604 | 0.79 | AR (0.52) | ARGPR119FFAR4PIK3CDPIK3CA | |
| SCHEMBL2474849 | 0.79 | USP30 (0.54) | USP30 | |
| SCHEMBL3290157 | 0.79 | HRH3 (0.64) | GPR119HRH3EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240441-A1 | PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES | Sanofi-Aventis (FR) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009080335-A1 | PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES | SANOFI-AVENTIS (FR) | 2009-07-02 | — | — | WO | disclosed |