SCHEMBL3670533

SCHEMBL3670533

COc1[c]cc(Br)cc1-c1cc(C(F)(F)F)ccc1Cl

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
BIRC5 O15392 1/20 0.38
PDE2A O00408 5/20 0.37
CYP1A2 P05177 3/20 0.34
CYP3A4 P08684 3/20 0.34
CYP2C19 P33261 3/20 0.34
MAPT P10636 1/20 0.34
CYP2C9 P11712 1/20 0.34
CTSA P10619 2/20 0.34
CYP2D6 P10635 2/20 0.33
HSD11B1 P28845 2/20 0.33
CTSS P25774 1/20 0.33
CTSK P43235 1/20 0.33
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
KDM1A O60341 1/20 0.32
AGPAT2 O15120 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3670534 0.76 CYP1A2 (0.36) BIRC5PDE2ACYP1A2CYP3A4CYP2C19
SCHEMBL6785539 0.75 BIRC5 (0.38) BIRC5PDE2AMAPTCTSSCTSK
SCHEMBL19785385 0.72 PDE2A (0.47) BIRC5PDE2ACYP1A2CYP3A4CYP2C19
SCHEMBL4439373 0.71 AMY1A (0.33) MAPTAGPAT2
SCHEMBL29134461 0.69
SCHEMBL3663441 0.69 CYP1A1 (0.32)
SCHEMBL3411258 0.69 KDM1A (0.38) BIRC5PDE2ACYP1A2CYP3A4CYP2C19
SCHEMBL16858738 0.69 KMT2A (0.35) PDE2ACYP1A2CYP3A4CYP2C19MAPT
SCHEMBL8622856 0.68 ALOX5AP (0.31)
SCHEMBL6785541 0.67 CTSS (0.38) BIRC5PDE2ACTSSCTSKMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2238133-A2 FUNGICIDAL AMIDES E. I. du Pont de Nemours and Company (US) 2010-10-13 EP disclosed
WO-2009094407-A2 FUNGICIDAL AMIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2009-07-30 WO disclosed