Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betamethasone Valerate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 9/20 | 0.70 |
| ▸ | PGR | P06401 | 4/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.70 |
| ▸ | USP2 | O75604 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.65 |
| ▸ | MMP1 | P03956 | 6/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MLNR | O43193 | 1/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrocortisone Butyrate SCHEMBL3670655 | 0.90 | KMT2A (0.59) | NR3C1PGRCYP3A4USP2KMT2A | |
| Hydrocortisone Butyrate SCHEMBL22042329 | 0.89 | NR3C2 (0.63) | NR3C1PGRCYP3A4USP2KMT2A | |
| Clobetasone Butyrate SCHEMBL22042328 | 0.87 | LMNA (0.69) | NR3C1PGRCYP3A4USP2KMT2A | |
| Halobetasol Propionate SCHEMBL4633197 | 0.87 | PGR (0.62) | NR3C1PGRCYP3A4USP2KMT2A | |
| Hydrocortisone Butyrate SCHEMBL8584180 | 0.86 | NR3C2 (0.66) | NR3C1PGRCYP3A4USP2KMT2A | |
| Betamethasone Valerate SCHEMBL9768470 | 0.84 | NR3C1 (1.00) | NR3C1PGRCYP3A4USP2KMT2A | |
| Betamethasone Valerate SCHEMBL7564753 | 0.84 | NR3C1 (1.00) | NR3C1PGRCYP3A4USP2KMT2A | |
| Betamethasone Valerate SCHEMBL221479 | 0.84 | NR3C1 (1.00) | NR3C1PGRCYP3A4USP2KMT2A | |
| Betamethasone Valerate SCHEMBL14339612 | 0.84 | NR3C1 (1.00) | NR3C1PGRCYP3A4USP2KMT2A | |
| Betamethasone Valerate SCHEMBL14339607 | 0.84 | NR3C1 (1.00) | NR3C1PGRCYP3A4USP2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE41278-E1 | N-acetyl aldosamines and related N-acetyl compounds, and their topical use | TRISTRATA, INC. | 2010-04-27 | — | — | US | claimed |