Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.34 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3622338 | 1.00 | MEN1 (0.35) | MEN1GAAKMT2ANOS1NOS3 | |
| SCHEMBL6230762 | 1.00 | MEN1 (0.35) | MEN1GAAKMT2ANOS1NOS3 | |
| SCHEMBL28058283 | 0.86 | KMT2A (0.36) | MEN1GAAKMT2ANOS1NOS3 | |
| SCHEMBL3809238 | 0.84 | NOS1 (0.33) | MEN1GAAKMT2ANOS1NOS3 | |
| SCHEMBL473544 | 0.84 | NOS1 (0.33) | MEN1GAAKMT2ANOS1NOS3 | |
| SCHEMBL28086859 | 0.82 | TDP1 (0.42) | MEN1GAAKMT2ANOS1NOS3 | |
| SCHEMBL28086861 | 0.82 | TDP1 (0.42) | MEN1GAAKMT2ANOS1NOS3 | |
| SCHEMBL3619677 | 0.80 | CTSK (0.33) | MEN1GAAKMT2ANOS1NOS3 | |
| SCHEMBL4537975 | 0.79 | FOLH1 (0.40) | MEN1GAAKMT2A | |
| SCHEMBL9644345 | 0.79 | NOS1 (0.32) | MEN1GAAKMT2ANOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101801965-B | Indole compounds as inhibitors of cellular necrosis | LG LIFE SCIENCES LTD | 2014-07-30 | — | — | CN | disclosed |
| CN-101801965-A | Indole compounds as inhibitors of cellular necrosis | LG LIFE SCIENCES LTD | 2010-08-11 | — | — | CN | disclosed |
| EP-2178869-A1 | INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG Life Sciences Ltd. (KR) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009025477-A1 | INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD. (KR) | 2009-02-26 | — | — | WO | disclosed |
| CN-1097052-C | Process for prodn. of amidinoindole derivatives and salts thereof | DAIICHI SEIYAKU CO (JP) | 2002-12-25 | — | — | CN | disclosed |
| CN-1062865-C | Process for production of amidinobenzofuran and amidionbenzothiophen derivatives and salt thereof | DAIICHI SEIYAKU CO (JP) | 2001-03-07 | — | — | CN | disclosed |
| CN-1168886-A | Process for production of amidinobenzofuran and amidionbenzothiophen derivatives and salt thereof | DAIICHI SEIYAKU CO (JP) | 1997-12-31 | — | — | CN | disclosed |
| CN-1168885-A | Process for prodn. of amidinoindole derivatives and salts thereof | DAIICHI SEIYAKU CO (JP) | 1997-12-31 | — | — | CN | disclosed |