Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.54 |
| ▸ | GAA | P10253 | 6/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.43 |
| ▸ | MEN1 | O00255 | 9/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25775831 | 0.80 | LMNA (0.64) | LMNAALDH1A1KDM4EGAAGLA | |
| SCHEMBL17331499 | 0.76 | ALDH1A1 (0.48) | LMNAALDH1A1KDM4EGAAGLA | |
| SCHEMBL4510814 | 0.76 | LMNA (0.59) | LMNAALDH1A1KDM4EGAAGLA | |
| SCHEMBL4918574 | 0.75 | KDM4E (0.54) | LMNAALDH1A1KDM4EGAAGLA | |
| SCHEMBL3842831 | 0.73 | LMNA (0.56) | LMNAALDH1A1KDM4EGAAGLA | |
| SCHEMBL4967007 | 0.71 | ALDH1A1 (0.49) | LMNAALDH1A1KDM4EGAAGLA | |
| SCHEMBL16175964 | 0.70 | KDM4E (1.00) | LMNAALDH1A1KDM4EGAAGLA | |
| SCHEMBL4910987 | 0.70 | SMN1; SMN2 (0.61) | ALDH1A1KDM4EGAAGLAHPGD | |
| SCHEMBL3668186 | 0.70 | KDM4E (0.48) | LMNAALDH1A1KDM4EGAAGLA | |
| SCHEMBL365090 | 0.67 | ALDH1A1 (0.68) | LMNAALDH1A1KDM4EGAAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152674-A1 | BENZIMIDAZOLONE CHYMASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008147697-A1 | BENZIMIDAZOLONE CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-04 | — | — | WO | disclosed |