Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22982704 | 0.82 | MAPT (0.58) | NPC1RAB9APTPN1KMT2AMEN1 | |
| SCHEMBL17301675 | 0.81 | NPC1 (0.64) | NPC1RAB9AHTR7PTPN1HSD11B1 | |
| SCHEMBL15973607 | 0.81 | MAPT (0.58) | NPC1RAB9AHTR7PTPN1HSD11B1 | |
| SCHEMBL26584242 | 0.80 | NPC1 (0.82) | NPC1RAB9AHTR7PTPN1HSD11B1 | |
| SCHEMBL14294951 | 0.79 | NPC1 (0.62) | NPC1RAB9AHTR7PTPN1HSD11B1 | |
| SCHEMBL9775167 | 0.79 | CA12 (0.57) | NPC1RAB9AHTR7HSD11B1KMT2A | |
| Hydrochloric Acid SCHEMBL31280787 | 0.78 | NPC1 (0.60) | NPC1RAB9AHTR7PTPN1HSD11B1 | |
| SCHEMBL19133492 | 0.76 | NPC1 (0.67) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL315309 | 0.76 | RAB9A (0.69) | NPC1RAB9AHTR7PTPN1HSD11B1 | |
| SCHEMBL4485908 | 0.76 | RAB9A (0.69) | NPC1RAB9AHTR7PTPN1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680281-B2 | Lactam inhibitors of 11-β-hydroxysteroid dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. (US) | 2014-03-25 | — | — | US | disclosed |
| EP-2240448-A1 | LACTAM INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | Vitae Pharmaceuticals, Inc. (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009088997-A1 | LACTAM INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-07-16 | — | — | WO | disclosed |