Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.57 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | CA9 | Q16790 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.49 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205108 | 0.90 | NPC1 (0.62) | CA12CA1CA2CA9NPC1 | |
| SCHEMBL3070244 | 0.89 | CA12 (0.69) | CA12CA1CA2CA9KMT2A | |
| SCHEMBL6201893 | 0.84 | ALDH1A1 (0.59) | NPC1RAB9AKMT2AMEN1HSD11B1 | |
| SCHEMBL4485908 | 0.81 | RAB9A (0.69) | NPC1RAB9AKMT2AMEN1HSD11B1 | |
| SCHEMBL21424286 | 0.80 | KMT2A (0.73) | KMT2AMEN1L3MBTL1ATMPOLB | |
| SCHEMBL13139118 | 0.80 | MAPT (0.64) | CA12CA1CA2CA9NPC1 | |
| SCHEMBL7348869 | 0.79 | ALDH1A1 (0.61) | NPC1RAB9AKMT2AMEN1HSD11B1 | |
| SCHEMBL23597429 | 0.79 | MAPT (0.62) | CA12CA1CA2CA9NPC1 | |
| SCHEMBL3672269 | 0.79 | NPC1 (0.60) | NPC1RAB9AKMT2AMEN1HSD11B1 | |
| SCHEMBL5245124 | 0.78 | ALDH1A1 (0.47) | CA12CA1CA2CA9NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5075339-A | Antiinflammatory agents, antiallergens | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-12-24 | — | — | US | disclosed |
| US-4948813-A | Benzylketone phospholipase A2 inhibitors | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-08-14 | — | — | US | disclosed |