SCHEMBL315309

SCHEMBL315309

O=C(O)CCC(=O)c1ccc(F)cc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 2/20 0.69
NPC1 O15118 1/20 0.69
NR4A2 P43354 1/20 0.65
KMT2A Q03164 1/20 0.64
SMN1; SMN2 Q16637 2/20 0.62
FFAR1 O14842 1/20 0.62
LMNA P02545 1/20 0.62
CYP1A2 P05177 1/20 0.62
HIF1A Q16665 1/20 0.62
HTR7 P34969 1/20 0.60
ALDH1A1 P00352 1/20 0.59
GAA P10253 1/20 0.59
CYP2C19 P33261 1/20 0.59
USP5 P45974 1/20 0.58
PTPN1 P18031 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.56
HSD11B1 P28845 1/20 0.54
MMP2 P08253 1/20 0.53
MMP12 P39900 1/20 0.53
CTNNB1 P35222 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7864069 0.94 SMN1; SMN2 (0.72) RAB9ANPC1NR4A2KMT2ASMN1; SMN2
SCHEMBL26584242 0.91 NPC1 (0.82) RAB9ANPC1KMT2ASMN1; SMN2HTR7
SCHEMBL10353454 0.89 NR4A2 (0.81) RAB9ANPC1NR4A2KMT2ASMN1; SMN2
SCHEMBL296337 0.88 NPC1 (0.84) RAB9ANPC1NR4A2KMT2ASMN1; SMN2
SCHEMBL3866967 0.88 NPC1 (0.77) RAB9ANPC1NR4A2KMT2ASMN1; SMN2
SCHEMBL4485908 0.87 RAB9A (0.69) RAB9ANPC1NR4A2KMT2ASMN1; SMN2
SCHEMBL6932000 0.86 TP53 (0.60) RAB9ANPC1NR4A2KMT2ASMN1; SMN2
SCHEMBL9953589 0.86 NPC1 (0.74) RAB9ANPC1KMT2ASMN1; SMN2LMNA
SCHEMBL6925985 0.85 MITF (0.66) RAB9ANPC1KMT2ALMNAPTPN1
SCHEMBL28225958 0.85 RAB9A (0.51) RAB9ANPC1NR4A2KMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 494 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4661890-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS Purdue Research Foundation (US) 2025-12-17 EP claimed
WO-2025151884-A1 USE OF GLYCOSAMINOGLYCAN SULFATED POLYSACCHARIDES SUCH AS SODIUM PENTOSAN POLYSULFATE IN COMBINATION WITH PERMEATION AGENTS TO TREAT ALZHEIMER'S DISEASE PARSONS C LOWELL (US) 2025-07-17 WO claimed
WO-2024167565-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS PURDUE RESEARCH FOUNDATION (US) 2024-08-15 WO claimed
CN-113214195-B Method for asymmetrically synthesizing dihydrofuran 2- (3H) -ketone compound by nickel catalysis 云南民族大学 2024-05-10 CN claimed
US-11884628-B2 Method for synthesizing lactam derivatives without use of catalyst GUIZHOU UNIVERSITY (CN) 2024-01-30 US claimed
US-20220177429-A1 METHOD FOR SYNTHESIZING LACTAM DERIVATIVES WITHOUT USE OF CATALYST GUIZHOU UNIVERSITY (CN) 2022-06-09 US claimed
CN-113214195-A Method for asymmetrically synthesizing dihydrofuran 2- (3H) -ketone compound by nickel catalysis 云南民族大学 2021-08-06 CN claimed
WO-2020228170-A1 CATALYST-FREE SYNTHESIS METHOD FOR LACTAM DERIVATIVE 贵州大学 2020-11-19 WO claimed
CN-109942473-B Method for synthesizing lactam derivative without catalyst 贵州大学 2020-09-15 CN claimed
US-10072043-B2 Inhibitors of protein tyrosine phosphatases INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2018-09-11 US claimed
WO-2010118241-A2 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) 2010-10-14 WO claimed
US-7732625-B2 Colorant compounds XEROX CORPORATION (US) 2010-06-08 US claimed
US-20080167217-A1 aryl ketone compounds and compositions containing them which facilitate the delivery of active agents. The aryl ketone compounds have the formula** Image-1or a salt thereof, where n=1 to 9, and R1 to R5 are independently hydrogen, C1 to C4 alkyl, C1 to C4 alkoxy, C2 to C4 alkenyl, halogen, hydroxyl, EMISPHERE TECHNOLOGIES, INC. (US) 2008-07-10 US claimed
US-7311767-B2 Forming a salt of a liquid phase change ink carrier of stearyl stearamide, an amine substituted Xanthene, acridine, anthracene or thioxanthene chromogen, and a metal salt capable of forming a compound with two chromogens XEROX CORPORATION (US) 2007-12-25 US claimed
US-7033424-B2 Phase change inks XEROX CORPORATION (US) 2006-04-25 US claimed
US-20060021546-A1 Processes for preparing phase change inks XEROX CORPORATION 2006-02-02 US claimed
US-20060020141-A1 Metallized dye XEROX CORPORATION 2006-01-26 US claimed
US-20060016369-A1 PHASE CHANGE INKS XEROX CORPORATION 2006-01-26 US claimed
US-6946025-B2 Process for preparing tetra-amide compounds XEROX CORPORATION (US) 2005-09-20 US claimed
US-20050090690-A1 Process for preparing tetra-amide compounds XEROX CORPORATION 2005-04-28 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10072043-B2 Inhibitors of protein tyrosine phosphatases PTPRCAP, PTPRF, PTPRS RAB9A 2114/4885NPC1 3543/4885NR4A2 3703/4885
US-11884628-B2 Method for synthesizing lactam derivatives without use of catalyst COASY, SI, NAAA RAB9A 1712/4885NPC1 4156/4885NR4A2 4625/4885
US-20060020141-A1 Metallized dye CDYL, CDY1; CDY1B, CDYL2 RAB9A 711/4885NPC1 3732/4885NR4A2 801/4885
US-20050090690-A1 Process for preparing tetra-amide compounds TAF9, TAF5, TAF1 RAB9A 789/4885NPC1 3601/4885NR4A2 2413/4885
US-20220177429-A1 METHOD FOR SYNTHESIZING LACTAM DERIVATIVES WITHOUT USE OF CATALYST COASY, SI, NAAA RAB9A 1712/4885NPC1 4156/4885NR4A2 4625/4885
US-20080167217-A1 aryl ketone compounds and compositions containing them which facilitate the delivery of active agents. The aryl ketone compounds have the formula** Image-1or a salt thereof, where n=1 to 9, and R1 to R5 are independently hydrogen, C1 to C4 alkyl, C1 to C4 alkoxy, C2 to C4 alkenyl, halogen, hydroxyl, AKR1C3, AKR1C1, AKR1A1 RAB9A 1402/4885NPC1 21/4885NR4A2 738/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.